Aerodynamic particle size analysis of a metered dose inhalation containing 100μg salbutamol sulphate in a single dose

The product beingness tested is a salamol chlorofluorocarbon-free Easi-Breathe respirator separately actuation of the inhalator delivers Salbutamol Sulphate Ph Eur equivalent to Salbutamol c micrograms into the mouthpiece of the adapter. Salbutamol is a selective ?2-adrenoceptor agonist. At therapeutic demigods it acts on the ?2-adrenoceptors of bronchial glint muscle providing short acting (4-6 hour) bronchodilatation with a fast trespass (within 5 minutes) in reversible airways obstruction. Salamol is indicated in the management of bronchial asthma, for the relief of wheezing and shortness of breather apply on an as required basis. The respirator whitethorn be used as necessary to relieve attacks of stabbing dyspnoea and may be used prophylactically before effort or to counter exercise-induced asthma. The inhaler may also be used in the treatment of the reversible component of airways obstruction. The metered dose inhaler (MDI) being is used in this experiment is the salamol inhaler as antecedently mentioned. It is a relatively new inhaler on the British market. The contents of the MDI are Norflurane (HFA 134a) Ethanol anhydrous and Salbutamol Sulphate. The inhaler ticks a new propellant and does not contain chlorofluorocarbons (CFCs). In the past the chief(prenominal) propellants used in inhalers were all CFC based which had a detrimental effect on the Ozone layer.

collect to the International ordinance of the Montreal Protocol, an international agreement on targets for the extermination of CFCs and HCFCs signed by 58 countries in 1990, the pharmaceutic attention are presently exempted from this ban on CFCs, but this granting immunity is r eviewed annually. This has forced the pharma! ceutical industry to seek more ozone congenial propellants. The norflurane (HFA 134a) acts as the propellant, in the easi-breathe, which is a hydroflurocarbon (HFA) and is Ozone friendly. The drug substance is scatter in the propellant, upon dot the propellant and the drug are dispersed... If you pauperization to get a full essay, order it on our website: OrderEssay.net

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